abstract：OBJECTIVE:Although C-reactive protein (CRP) and albuminuria are well-documented cardiovascular risk markers, the functional implications of these biomarkers and their combination on functional disability and metabolic risks in patients with cardiovascular disease (CVD) are unknown. METHODS:Data were from 1403 adults (...

journal_title：Atherosclerosis

authors： Kuo HK,Al Snih S,Kuo YF,Raji MA

更新日期：2012-06-01 00:00:00

abstract：AIM:Serum paraoxonase 1 (PON1) is an HDL-associated lipolactonase and its association with hypertension is controversial. We studied the possible role of PON1 in blood pressure (BP) regulation, by using PON1 knockout (PON1KO) mice. METHODS AND RESULTS:Both, systolic and diastolic BPs were lower in PON1KO compared to W...

journal_title：Atherosclerosis

authors： Gamliel-Lazarovich A,Abassi Z,Khatib S,Tavori H,Vaya J,Aviram M,Keidar S

更新日期：2012-05-01 00:00:00

abstract：:To elucidate the associations between Lp(a) levels and coronary and aortic atherosclerosis, we performed aortic MRI in 143 patients undergoing coronary angiography. Severity of aortic atherosclerosis was represented as plaque scores. Of the 143 patients, 104 had coronary artery disease (CAD). Thoracic and abdominal ao...

journal_title：Atherosclerosis

authors： Momiyama Y,Ohmori R,Fayad ZA,Tanaka N,Kato R,Taniguchi H,Nagata M,Ohsuzu F

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:An elevated systolic blood pressure (SBP) response to a graded maximal exercise stress test (GEST) may be a predictor of endothelial dysfunction and hypertension. We examined relationships among the GEST peak SBP response and indicators of endothelial function. METHODS:Men (n=48, 43.7±1.4 yr) with high BP (145...

journal_title：Atherosclerosis

authors： Olson KM,Augeri AL,Seip RL,Tsongalis GJ,Thompson PD,Pescatello LS

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The influence of hepatitis C virus (HCV) infection on atherosclerosis risk in HIV-infected patients has not been adequately evaluated in real-life situations. OBJECTIVES AND METHODS:We compared indexes of early atherosclerosis evaluated by echo-Doppler ultrasound (presence of plaque in carotid or femoral ar...

journal_title：Atherosclerosis

authors： Sosner P,Wangermez M,Chagneau-Derrode C,Le Moal G,Silvain C

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Atherogenic dyslipidemia (AD), characterized by high plasma triglycerides and low HDL particles, is considered one of the main effectors of vascular damage associated with obesity, metabolic syndrome (MS) and type 2 diabetes. Adipocyte fatty acid-binding protein (FABP4) plasma concentrations have been linked ...

journal_title：Atherosclerosis

authors： Cabré A,Babio N,Lázaro I,Bulló M,Garcia-Arellano A,Masana L,Salas-Salvadó J

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Vascular calcification is an active deposition process of calcium phosphate which resembles bone formation and is highly regulated by osteoblast-like cells. Existing studies demonstrate that advanced glycation end-products (AGEs) may play a pathogenic role in the vascular calcification process. However, their...

journal_title：Atherosclerosis

authors： Wang Z,Jiang Y,Liu N,Ren L,Zhu Y,An Y,Chen D

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). METHODS:We compared 28 mg/kg crystalline IR niacin, equimolar doses of crystalline IR ST0702 and control on low densit...

journal_title：Atherosclerosis

authors： Ledwidge MT,Ryan F,Kerins DM,O'Connell D,Cefali G,Harmon S,Jones M,Gilmer JF

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:A common gain-of-function LPL variant, LPLS447X, has favorable clinical features and involves a C→G base change at nucleotide 1595 of the LPL cDNA, along with a haplotype, which includes other non-coding SNPs. The mechanism for the LPL gain-in-function is not clear. LPL translation is regulated by epinephrine...

journal_title：Atherosclerosis

authors： Ranganathan G,Unal R,Pokrovskaya ID,Tripathi P,Rotter JI,Goodarzi MO,Kern PA

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:Our study aimed to evaluate the effects of psoriasis (Pso) on coronary microvascular function and whether there is a relationship between disease activity scores and coronary blood flow abnormalities. METHODS:56 young patients (pts) with Pso (42 M, aged 37±3 years) without clinical evidence of cardiovascular...

journal_title：Atherosclerosis

authors： Osto E,Piaserico S,Maddalozzo A,Forchetti G,Montisci R,Famoso G,Giovagnoni A,Peserico A,Iliceto S,Tona F

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) play a pivotal role in neointima hyperplasia after balloon injury. Molecular hydrogen has emerged as a novel antioxidant and has been proven effective in treating many diseases. OBJECTIVES:We aimed to determine the mechanism by which hydrogen affects neointima formation. METHO...

journal_title：Atherosclerosis

authors： Qin ZX,Yu P,Qian DH,Song MB,Tan H,Yu Y,Li W,Wang H,Liu J,Wang Q,Sun XJ,Jiang H,Zhu JK,Lu W,Huang L

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Receptor-associated protein (RAP) was initially described as a regulator of low density lipoprotein receptor-related protein 1 (LRP1), but is now known to regulate many proteins. Since the direct effects of RAP on vascular pathologies have not been studied, this study determined whether RAP deficiency influen...

journal_title：Atherosclerosis

authors： Wang S,Subramanian V,Lu H,Howatt DA,Moorleghen JJ,Charnigo R,Cassis LA,Daugherty A

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:In this study, we compared the changes in arterial stiffness in chronic hemodialysis patients treated with 8-h vs. 4-h thrice weekly in-center hemodialysis. METHODS:Sixty prevalent chronic hemodialysis patients assigned to 8-h nocturnal in-center thrice weekly HD (NHD) and 60 control cases assigned to 4-h th...

journal_title：Atherosclerosis

authors： Demirci MS,Celik G,Ozkahya M,Tumuklu M,Toz H,Asci G,Duman S,Basci A,Kircelli F,Ozdogan O,Demirci C,Can L,Isik IO,Ok E,Long Dialysis Group.

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary heart disease (CHD) risk. However, these associations may be modified by lifestyle factors. Therefore, we studied whether smoking, physical inactivity or overweight interact with APOE on cholesterol levels and CHD risk. METHODS:C...

journal_title：Atherosclerosis

authors： Gustavsson J,Mehlig K,Leander K,Strandhagen E,Björck L,Thelle DS,Lissner L,Blennow K,Zetterberg H,Nyberg F

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Serum adiponectin protects against incident ischemic heart disease (IHD). However, in patients with existing IHD, higher adiponectin levels are paradoxically associated with worse outcomes. We investigated this paradox by evaluating the relationship between adiponectin and cardiovascular events in patients wi...

journal_title：Atherosclerosis

authors： Beatty AL,Zhang MH,Ku IA,Na B,Schiller NB,Whooley MA

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Epicardial adipose tissue (EAT) mass correlates with metabolic syndrome and coronary artery disease (CAD). However, little is known about the expression of genes involved in triglyceride (TG) storage and mobilization in EAT. We therefore analyzed the expression of genes involved in fat mobilization in EAT in...

journal_title：Atherosclerosis

authors： Jaffer I,Riederer M,Shah P,Peters P,Quehenberger F,Wood A,Scharnagl H,März W,Kostner KM,Kostner GM

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Gamma-globulin treatment reduces experimental atherosclerosis by modulating immune function; however the effect of IgM on atherosclerosis is not known. We investigated the effect of serum-derived, non-immune polyclonal IgM (Poly-IgM) on atherosclerosis in mice with advanced disease and also assessed its immun...

journal_title：Atherosclerosis

authors： Cesena FH,Dimayuga PC,Yano J,Zhao X,Kirzner J,Zhou J,Chan LF,Lio WM,Cercek B,Shah PK,Chyu KY

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...

journal_title：Atherosclerosis

authors： Inaba Y,Chen JA,Bergmann SR

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...

journal_title：Atherosclerosis

authors： Evans D,Aberle J,Beil FU

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Previous studies indicate an association between marathon running and premature atherosclerosis. Retinal vessel diameter alterations, in particular narrower arterioles and wider venules, reflect early stages of atherosclerosis, but the influence of marathon on the retinal microcirculation is unknown. METHODS...

journal_title：Atherosclerosis

authors： Pressler A,Hanssen H,Dimitrova M,Krumm M,Halle M,Scherr J

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:P2X(7) receptor (P2X(7)R), upon its stimulation with extracellular ATP, modulates several inflammatory responses in different cell types. No information is available on its presence in human adipocytes and its potential involvement in the chronic inflammation associated with metabolic syndrome (MS). Therefore...

journal_title：Atherosclerosis

authors： Madec S,Rossi C,Chiarugi M,Santini E,Salvati A,Ferrannini E,Solini A

更新日期：2011-12-01 00:00:00

abstract：:Cardiovascular disease (CVD) is currently the second most frequent cause of death (after cancer) among HIV-positive subjects. The clinical use of highly active antiretroviral therapy (HAART) has dramatically reduced mortality and morbidity in HIV-positive population, leading to prolonged and improved quality of life. ...

journal_title：Atherosclerosis

authors： Giannarelli C,Klein RS,Badimon JJ

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Peritoneal macrophages are used in many studies related to atherosclerosis. In situ, they are non-adherent and upon culturing, they adhere and function as scavengers of modified lipoproteins and dead apoptotic cells. They also produce growth factors, suggesting that they may provide life-supporting function a...

journal_title：Atherosclerosis

authors： Selvarajan K,Moldovan L,Chandrakala AN,Litvinov D,Parthasarathy S

更新日期：2011-12-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea results in nocturnal intermittent hypoxia (IH) as a main trigger for cardiovascular morbidity, including atherosclerosis. IH induces hemodynamic, hormono-metabolic and also immuno-inflammatory alterations that could differentially contribute to atherosclerosis. Our study aimed at exami...

journal_title：Atherosclerosis

authors： Arnaud C,Poulain L,Lévy P,Dematteis M

更新日期：2011-12-01 00:00:00

abstract：:High level of plasma very low-density lipoprotein (VLDL) has been identified as a risk factor for coronary heart disease. Recent evidence suggests that excess VLDL induces inflammatory responses in macrophages and vascular endothelial cells. The Japan EPA Lipid Intervention Study (JELIS), a large scale clinical trial,...

journal_title：Atherosclerosis

authors： Jinno Y,Nakakuki M,Kawano H,Notsu T,Mizuguchi K,Imada K

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol c...

journal_title：Atherosclerosis

authors： Kohsaka S,Jin Z,Rundek T,Homma S,Sacco RL,Di Tullio MR

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:The goal of the study was to examine possible sex-related differences in the clinical characteristics and risk factors in Japanese patients with peripheral arterial disease (PAD). METHODS:Sex-related differences in clinical profiles, risk factors and treatments were examined in 730 consecutive patients with ...

journal_title：Atherosclerosis

authors： Kumakura H,Kanai H,Araki Y,Kasama S,Sumino H,Ito T,Iwasaki T,Takayama Y,Ichikawa S,Fujita K,Nakashima K,Minami K

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness. METHODS:The case-control st...

journal_title：Atherosclerosis

authors： Zou Z,Xu X,Huang Y,Xiao X,Ma L,Sun T,Dong P,Wang X,Lin X

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of resistance training (RT) on the metabolism of an LDL-like nanoemulsion and on lipid transfer to HDL, an important step of HDL metabolism. METHODS:LDL-like nanoemulsion plasma kinetics was studied in 15 healthy men under regular RT for 1-4 years (age = 25 ± 5 years, VO(2)peak = 50 ±...

journal_title：Atherosclerosis

authors： da Silva JL,Vinagre CG,Morikawa AT,Alves MJ,Mesquita CH,Maranhão RC

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Emerging data suggests that 3-dimensional (D) ultrasound (US) may provide us with a new tool for the identification of the vulnerable carotid plaque. METHODS:A systematic review of the PubMed, Scopus and Cochrane databases regarding the reproducibility and effectiveness of 3D US in evaluation of carotid p...

journal_title：Atherosclerosis

authors： Makris GC,Lavida A,Griffin M,Geroulakos G,Nicolaides AN

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variab...

journal_title：Atherosclerosis

authors： Prudente S,Morini E,Larmon J,Andreozzi F,Di Pietro N,Nigro A,Gervino EV,Mannino GC,Bacci S,Hauser TH,Bellacchio E,Formoso G,Pellegrini F,Proto V,Menzaghi C,Frittitta L,Pandolfi A,Sesti G,Doria A,Trischitta V

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:A low circulating level of bilirubin is associated with increased cardiovascular risk. As statins can stimulate heme oxygenase-1 (HO-1), which increases bilirubin production, we investigated whether statins in routine use increase total bilirubin levels in subjects at high cardiovascular risk. METHODS:Data f...

journal_title：Atherosclerosis

authors： Ong KL,Wu BJ,Cheung BM,Barter PJ,Rye KA

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Fetal exposure to maternal hypercholesterolemia increases the extent of fatty-streak formation in fetal aortas as well as the rate of progression, and may therefore increase coronary heart disease (CHD) risk later in life. We hypothesized that the risk of CHD in untreated individuals with familial hypercholes...

journal_title：Atherosclerosis

authors： Versmissen J,Botden IP,Huijgen R,Oosterveer DM,Defesche JC,Heil TC,Muntz A,Langendonk JG,Schinkel AF,Kastelein JJ,Sijbrands EJ

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To analyze paraoxonase 1 (PON1) effect on monocyte-to-macrophage differentiation. METHODS AND RESULTS:THP-1 monocytic cell-line and mouse peritoneal macrophages (MPM) were studied. Markers for monocytes differentiation included: morphological changes, CD11b and CD36 expression, and cellular oxidative stress....

journal_title：Atherosclerosis

authors： Rosenblat M,Volkova N,Ward J,Aviram M

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study. METHODS:In the population-based...

journal_title：Atherosclerosis

authors： Lind PM,Lind L

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are complex pathologies characterized by lipid accumulation, chronic inflammation and extensive tissue remodelling. Microparticles (MPs), small membrane vesicles produced by activated and apoptotic cells, might not only be biomarkers, but also fun...

journal_title：Atherosclerosis

authors： Baron M,Leroyer AS,Majd Z,Lalloyer F,Vallez E,Bantubungi K,Chinetti-Gbaguidi G,Delerive P,Boulanger CM,Staels B,Tailleux A

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:We investigated whether statin-treated heterozygous familial hypercholesterolemic (FH) patients have lower plasma coenzyme Q(10) (CoQ(10)) levels than low-density lipoprotein receptor (LDLR) mutation negative FH patients on equivalent statin doses, and whether lower CoQ(10) concentrations are associated with ...

journal_title：Atherosclerosis

authors： Young JM,Molyneux SL,Reinheimer AM,Florkowski CM,Frampton CM,Scott RS,George PM

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Hemodynamic forces are potential determinants of aortic atherosclerosis. Aortic regurgitation (AR) alters the flow pattern in the aorta. However, the association between AR and aortic atherosclerosis is not well known. METHODS:We assessed the presence, extent and distribution of atherosclerotic lesions in th...

journal_title：Atherosclerosis

authors： Shimoni S,Zilberman L,Edri O,Bar I,Goland S,Gendelman G,Swissa M,Livshitz S,Paz O,Ayzenberg O,George J

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Th1 activation and regulatory T (Treg) cell suppression have been observed in acute coronary syndrome (ACS), including unstable angina (UA) and acute myocardial infarction (AMI). However, the role of Th17 cell or IL-17A remains controversial in ACS patients, and little is known about the role of recently disc...

journal_title：Atherosclerosis

authors： Zhao Z,Wu Y,Cheng M,Ji Y,Yang X,Liu P,Jia S,Yuan Z

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Previous studies have indicated that sleep duration is associated with total mortality in a U-shaped fashion. The purpose of the current study was to examine the relationship between self-reported sleep duration and carotid artery atherosclerosis in a Japanese population. METHODS:In 2009-2010, a total of 24...

journal_title：Atherosclerosis

authors： Abe T,Aoki T,Yata S,Okada M

更新日期：2011-08-01 00:00:00